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  • 09월 06일 11시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제112회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Engineered Nanomaterials for Enhanced Antitumor and Antiviral Effect

2013년 9월 2일 13시 24분 37초
POLY1-5 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 11시 : 05분
고분자화학 - Current Trends in Biomedical Polymers
저자 및
충남대학교 분석과학기술대학원 분석과학기술학과, Korea
The design and chemical synthesis of multifunctional nanomaterials have been providing potential applications in biomedical fields such as molecular imaging and drug delivery. Recently, bio-derived and/or synthetic nanostructured materials capable of modulating the immune system have been also issues of interest in immunology-related nanomedicine fields. In this talk, the recent research results on the development of nanostructured materials for enhanced immunity would be presented. In the first part, we have designed and synthesized an immunomodulatory hybrid nanoconjugates (HNC) system based on polymer nanocomposites containing quantum dots (QDs; as imaging tracers) that are decorated with CpG ODNs (as a TLR9 ligand) and STAT3 siRNAs (as an immunosuppressive gene silencer). These HNC efficiently targeted immune cells, induced TLR activation, and silenced immunosuppressive genes. Simultaneous in vivo delivery of STAT3 siRNA and CpG ODN to dendritic cells (DCs) in the tumor microenvironment induced both the inhibition of STAT3 and activation of DCs by CpG ODNs, and synergistically elicited anti-tumor effects. By using NIR-emitting QDs, the migration of in vivo DCs to lymph nodes was also tracked by real-time NIR fluorescence imaging. In the second part, we focus on the development of a nanodelivery system for the effective mucus delivery of a viral antigen that can induce strong mucosal immunity without additional immunostimulatory adjuvant materials, such as alum, emulsion, and cationic lipid. To accomplish this goal, we designed and synthesized a mucosal vaccine delivery system based on biosynthetic mucoadhesive polymer nanomicelles. We have also tested the adjuvant function of nanomicelles in the presence of an influenza A viral antigen, that is, the inactivated virus of influenza A/PuertoRico/ 8/34 (PR8;H1N1). Intranasal immunization with PR8 in the presence of nanomicelles induced high levels of functional antibodies and IFN-γ producing cells, suggesting that our nanomicelle system could function as an effective adjuvant for inducing both humoral and cellular immune responses.