abs

학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 09월 06일 15시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제112회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Preparation 2-Substituted-4-pyridylzinc Bromides via Direct Insertion of Active Zinc and Their Coupling Reactions

등록일
2013년 9월 2일 20시 24분 30초
접수번호
1279
발표코드
ORGN.P-876 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 16일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
조경환, 김승회*
단국대학교 화학과, Korea

Heterocyclic compounds which contain a pyridine moiety have played a very significant role in a wide range of organic compounds, such as pharmaceuticals, agrochemicals, medicinal chemistry, and material chemistry. For example, bipyridine groups were found to be a key element in antibiotics, and pyridylpyrimidines were used as fungicides as well as tyrosine kinase inhibitors. In addition, pyridinecontaining oligomers are frequently found in liquid crystals. More specific examples utilizing 4-pyridyl moiety are also found in a wide spread of fields in chemistry. Consequently, new practical synthetic approaches for introducing a pyridine ring into complex organic molecules are of high value. To this end, transition-metal-catalyzed cross-coupling reactions of pyridylmetallic reagents have been frequently utilized. However, the preparation of electron-deficient pyridyl organometallic reagents has been a challenging subject mainly because of some difficulties such as instability and formation of by-products. In addition to those difficulties, the regiochemistry should be considered when the corresponding pyridylmetallic reagents were prepared because, unlike benzene, pyridine ring has unevenly distributed electrons.


상단으로