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  • 09월 06일 15시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제112회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Dynamic Range of IR Probe

2013년 9월 3일 19시 06분 19초
PHYS.P-412 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 16일 (수요일) 16:00~19:00
저자 및
박광희, 조민행*
고려대학교 화학과, Korea
The site-specific IR probes, which were used for studying protein dynamics, should have not only structural sensitivities but also long vibrational lifetimes. Because the transient IR signals such as IR pump-probe and 2D IR signals can be measured only when the IR probes are in a vibrationally excited state. In this regard, developments of new IR probes with long vibrational lifetimes are very important for studying structural dynamics of proteins occurring on hundreds of picoseconds or even longer timescales. we studied the method of increasing lifetime of the IR probe to use the heavy atom between the peptide and probing molecules, which studied the structural dynamics of the proteins with IR probed petide. Using various IR probe-derivatized prolines, their lifetimes in D2O and chloroform are measured with polarization-controlled IR pump-probe spectroscopy. The measured lifetimes of 10~15 ps for azido stretch mode is short. The measured lifetimes of SeCN are 3-4 times longer than those of SCN, because that selenium atom effectively blocks the intramolecular vibrational relaxation pathways of the CN stretch mode. This result would be significant guideline for development of new IR probe, which used to studying structural dynamics of proteins.