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  • 09월 06일 15시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제112회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Rapid Diagnosis of Tuberculosis Using Quantum Nanoparticles and Recombinant Fusion Proteins

2013년 9월 5일 12시 41분 59초
BIO.P-600 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 16일 (수요일) 16:00~19:00
저자 및
김기욱, 박태정*
중앙대학교 화학과, Korea
The most effective Tuberculosis control strategy will prevent the spread of tuberculosis disease by treatment of its patients and early-stage detection. Therefore, an ideal tuberculosis diagnosis is fast and cost-effective, whereas does not require complex equipment and facilities should be able to use easily. It must be performed with the best conditions to measure antigen-antibody interactions. However, there are several problems to overcome and to measure the benefits of the tuberculosis antigens. We detected target antigens, CFP-10 and Ag85, which are known specific secretory antigens from Mycobacterium tuberculosis. M. tuberculosis in culture media secretes a large quantity of toxic materials to human in the early preliminary study, and they can be proven to be detected in the urine and phlegm. Sandwich-assay method based on fluorescent nanoparticles can be used by the amplification effect of the detection signal using quantum nanoparticle. Quantum dots (QDs) are nanometer scale particles as semiconducting materials, traditionally chalcogenides of metals, which range from 2 to 10 nanometers in diameter. We studied for the optimization of antigen-antibody interaction using QDs and the production of recombinant fusion proteins as their antibodies. As a result, we developed a rapid diagnosis method for tuberculosis to detect multiple antigens from clinical specimens by using nanomaterials and its composites.