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학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

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  • 09월 06일 15시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제112회 대한화학회 학술발표회, 총회 및 기기전시회 안내 A dendritic single-molecule fluorescent probe that is photostable and minimally blinking

등록일
2013년 9월 5일 13시 55분 57초
접수번호
1374
발표코드
ORGN.P-901 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 16일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
양시경
전남대학교 화학교육과, Korea
Single-molecule fluorescence techniques have emerged as a powerful approach to understanding complex biological systems. However, a challenge researchers still face is the limited photostability of nearly all organic fluorophores. We have developed a new, monovalent probe that emits in the far-red region of the visible spectrum with properties desirable for single-molecule optical imaging. This probe is based on a ring-fused boron-dipyrromethene (BODIPY) core that is conjugated to a polyglycerol dendrimer (PGD), making the hydrophobic fluorophore water-soluble. This probe exhibits excellent brightness with an emission maximum of 705 nm. We have observed strikingly long and stable emission from individual PGD?BODIPY probes, even in the absence of anti-fading agents such as Trolox, a combined oxidizing?reducing agent often used in single-molecule studies for improving the photostability of common imaging probes. These interesting properties greatly simplify use of the fluorophore and overcome a significant obstacle in single-molecule fluorescence imaging.

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