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  • 09월 06일 15시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제112회 대한화학회 학술발표회, 총회 및 기기전시회 안내 S-Benzyl isothiouronium iodide as an organocatalyst for the direct reductive amination of aldehydes and the reduction of conjugated nitroalkenes into nitroalkanes using Hantzsch ester

등록일
2013년 9월 5일 15시 59분 06초
접수번호
1416
발표코드
ORGN.P-906 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 16일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
이하늬, 김택현1,*
전남대학교 신화학소재공학과, Korea
1전남대학교 응용화학공학부 광바이오사업단, Korea
Reductive amination is one of the most powerful used methods of accessing different kinds of amines. In particular, when the carbonyl component is reacted directly with the amine and reducing agent, avoiding isolation of the imine intermediate. Hantzsch ester has proven to be a powerful reductive agent, because they overcome some of the problems encountered with traditional reductive reagents such as hydrogen gas/metal and metal hydrides, for instance, their limitations in the case of sensitive, acid-labile, or polyfuntional substrates. However, in some cases, this reducing agent was found to be ineffective without catalysis. Thioureas are powerful organocatalytic systems and can provide considerable reaction rate acceleration through hydrogen bond interactions. Isothiouroniums have been explored as prospective replacements of thioureas in the area of anion binding to enhance the acidity of the NH moieties and allow more hydrogen bonding. Isothiouronium salts have been explored quite recently as a new class of hydrogen-bonding subunit for the purpose of anion recognition. Herein, we will discuss the counter anions of S-benzyl isothiouronium effect the reaction rate and efficiency in the direct reductive amination of aldehydes and the reduction of conjugated nitroalkenes into nitroalkanes using Hantzsch ester.

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