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  • 09월 06일 15시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제112회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Summary on Development of Acetylcholinesterase Reactivators ― antidotes against nerve agents

2013년 9월 5일 16시 25분 31초
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금 11시 : 30분
유기화학 - Oral Presentation for Young Organic Chemists
저자 및
Kamil Kuca*, Kamil Musilek, Jiri Kassa, Daniel Jun, Jana Zdarova-Karasova, Ondrej Soukup, Martina Hrabinova, Jan Marek, Jan Korabecny, Vendula Sepsova, Rafael Dolezal1, Martin Kunes1
Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic, Czech Republic
1Biomedical Research Center, University Hospital Hradec Kralove, Czech Republic, Czech Republic
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승인 12건
No clinically used acetylcholinesterase (AChE) reactivators (pralidoxime, obidoxime, trimedoxime, MMB-4 and HI-6) can be used as a universal antidote for treatment of nerve agent intoxications. Although oxime HI-6 seems to be the best AChE reactivator, its potency to reactivate tabun and OP-pesticide inhibited AChE is limited. Due to this, hundreds of novel oxime candidates were synthesized and tested for their potency to reactivate nerve agent and OP-pesticide inhibited AChE within last ten years at our department. Two candidates were selected as the most promising reactivators ― oxime K027 (against pesticides) and oxime K203 (against tabun). Both compounds together with oxime HI-6 DMS are currently of our high interest and are well investigated in Czech Republic for their potential military and civilian use. In this contribution, summary on results obtained with these compounds will be presented. This work was supported by the grant of Ministry of Health (Czech Republic) No. NT12062 and A long ― term organization development plan 1011