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제112회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Interaction and Reactivity of Synthetic Flavonoids with Metal-Free and Metal-Associated Amyloid Species

2013년 9월 5일 16시 42분 08초
INOR.P-254 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 16일 (수요일) 16:00~19:00
저자 및
임미희*, Hyuck Jin Lee1, Alaina S. DeToma2
울산과학기술대학교(UNIST) 나노생명화학공학부, Korea
1Department of Chemistry, University of Michigan, Korea
2Department of Chemistry, University of Michigan, United States
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승인 2건
Disturbed metal ion homeostasis in conjunction with amyloid-β (Aβ) aggregation in the brain has been implicated in Alzheimer’s disease (AD) pathogenesis. To uncover the interplay between metal ions and Aβ peptides, multifunctional small molecules have been employed to monitor Aβ aggregation and toxicity in vitro. Naturally occurring flavonoids have emerged as a valuable class of compounds for this purpose due to their ability to modulate both metal-free and metal-induced Aβ aggregation leading to non-toxic amorphous peptide products; however, the structural moieties of flavonoids responsible for such reactivity have not been fully identified. Herein, we designed, synthesized, and characterized a set of synthetic flavonoids that interact with metal ions and Aβ species, modulate metal-free Aβ and metal?Aβ aggregation in vitro, and regulate toxicity induced by metal-free Aβ/metal?Aβ. Overall, through our studies we obtained valuable insights on the requirements for parity among metal chelation, intermolecular interactions, and substituent variation using synthetic flavonoids, which offer a basic fundamental understanding of a structure-interactionreactivity relationship between metal-free Aβ and metal?Aβ species with the flavonoid family.