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  • 09월 06일 11시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제112회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Biosensing of Determination of Glycated Hemoglobin (HbA1c) Based on Boronic Acid Modified Gold Electrode and Luminol Chemiluminescence

2013년 9월 6일 09시 14분 09초
ELEC-5 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 16시 : 45분
전기화학 - Recent Advances in Electrochemiluminescence (ECL) Technique
저자 및
연세대학교 화학과, Korea
Diabetes, a disorder in the metabolism of glucose due to the lack or inability to use insulin to regulate the glucose level, is one of the major health concerns worldwide. Therefore, the monitoring of glucose level is necessary to diabetic patients. Hemoglobin A1c level has been used as one of the reliable markers of glycemic control. The detection of hemoglobin A1c is very important because it indicates the average blood glucose level over 3 months. A chemiluminescene flow injection system was used to detect the hemoglobin A1c containing iron inside. In this study, we have used luminol chemiluminescence in the presence of H2O2, to measure Fe content inside of hemoglobin A1c. First, hemoglobin A1c was selectively bound into the SAM of boronic acid on a gold electrode surface, and then luminol and H2O2 were flown into the observation cell where the CL reaction take place and the light is measured. The present sensor responded linearly to HbA1c in the wide % range from 2.5% to 17% with a good sensitivity. Furthermore, the HbA1c % in human plasma samples was successfully determined and compared to the result obtained with other methods. Therefore, the chemiluminescene flow injection system detection of HbA1c sensor might be applied for the determination of HbA1c in the human blood samples.