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학술발표회초록보기

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  • 09월 06일 11시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제112회 대한화학회 학술발표회, 총회 및 기기전시회 안내 DNA Damage Analysis on Single Molecules

등록일
2013년 9월 11일 09시 35분 35초
접수번호
1466
발표코드
ANAL1-3 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 10시 : 10분
발표형식
심포지엄
발표분야
분석화학 - KCS-JASIS Joint Symposium: Advanced Separation Science
저자 및
공동저자
조규봉
서강대학교 화학과, Korea
Single molecule approaches are revolutionizing biochemical analysis because they pinpoint measurements to individual molecules in place of bulk assays, thereby engendering new molecular insights. Moreover, the capability of providing individual information makes single DNA molecule approaches useful for stochastic event analysis. For example, ultraviolet (UV) induced DNA damage is a stochastic event as well as a biologically important issue. Thus, here we present a single DNA molecule approach how to visualize UV-induced DNA damages such as double strand breaks (DSB) and single strand breaks (SSB) on DNA molecular backbones. Our molecular observations provide a map of DNA radiation-mediated breakages, revealing the sequence dependency of DNA damages rather than random occurrences. Consequently, our single molecule observations, along with simple genome analysis, imply that essential genes in bacteriophage may have a tolerance to UV irradiation.

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