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제113회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Tuning lateral packing densities of pOEGMA on gold surfaces and its impact on the amount of immobilized streptavidin

등록일
2014년 2월 5일 16시 31분 06초
접수번호
0080
발표코드
ORGN.P-588 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 16일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
고상원, 최인성1, 이정규2,*
한국철도기술연구원 에코시스템연구실, Korea
1한국과학기술원(KAIST) 화학과, Korea
2경북대학교 자연대/화학과, Korea
Biofouling, the accumulation of biological matters on a surface causing the deterioration of the device, is a problematic issue in a wide range of fields, such as biomedical devices/implants, biosensors, drug delivery carriers, and food industry. Recently, specific immobilization of biomolecules on non-biofouling polymeric films has received much attention, because it can serve as a platform for achieving highly sensitive biochips and biomedical devices. Previously reported results not only indicated that the amount of immobilized protein can be controlled by selection of reactive sites, but also encourage us to understand binding behaviors. Thus, we investigated binding behaviors of streptavidin with the different lateral packing densities of biotin-functionalized, non-biofouling pOEGMA brushes. pOEGMA was synthesized by surface-initiated polymerization from the mixed SAMs with different mole fractions of initiators on gold surfaces.

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