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제113회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Non-covalent Interactions Existed in Octameric β-Peptide Foldectures

2014년 2월 10일 11시 08분 25초
ORGN.P-602 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 16일 (수요일) 16:00~19:00
저자 및
공진택, 이희승*
한국과학기술원(KAIST) 화학과, Korea
Recently we have published unprecedented shapes of β-peptide self-assembled structures which were named foldecture (i.e. self-assembled foldamer)1. Study on the formation mechanism of foldecture is expected to give an intuition of formation process of various 3D materials in nature, such as protein folding. As the first step of the study, understanding of its molecular packing structure is essential. For this purpose, SDPD technique has been applied to foldectures.
Herein we present the result of structural analysis of a finite plate-shaped foldecture that was obtained by controlled self-assembly of ACPC8 and ACPC6Leu2 foldamers in aqueous solution, respectively. The molecular packing structures showed orthorhombic system, which clearly indicated three-different ways of molecular interaction in each a, b and c axis. The similar packing structures of both β-peptide foldectures indicate resemblance of formation process of the foldectures, which resulted in finite plate-shape.

1. (a) S. Kwon.; H.S. Shin.; J. Gong.; J.-H. Eom.; A. Jeon.; S.H. Yoo.; I.S. Chung.; S.J. Cho.; H.-S. Lee. J. Am. Chem. Soc. 2011, 133, 17618. (b) J. Kim.; S. Kwon.; S. H. Kim.; C.-K. Lee.; J.-H. Lee.; S. J. Cho.; H.-S. Lee.; H. Ihee. J. Am. Chem. Soc. 2012, 134, 20573. (c) S. Kwon.; A. Jeon.; S. H. Yoo.; I. S. Chung.; H.-S. Lee. Angew. Chem. Int. Ed. 2010, 49, 8232. 2. W. A. Dollase. J. Appl. Cryst. 1986, 19, 267.