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학술발표회초록보기

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결제문의 member@kcsnet.or.kr

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  • 02월 20일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제113회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Facile Synthesis of Licochalcone C

등록일
2014년 2월 13일 15시 55분 22초
접수번호
1047
발표코드
ORGN.P-769 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 16일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
김철기, 전종갑*
한림대학교 화학과, Korea
Several chalcone compounds have been extracted and characterized from Licorice, perennial herb which grows in southern Europe, China, Russia and Turkey. Among these chalcone compounds, licochalcone C have been extracted from Licorice in china, and known to have several promising biological activities (antimutagenic, antiparasitic, antileishmanial, anti-ulcer, anti-oxidative and anti-inflammatory effects). Biological activities of licohalcone C have been known such as antioxidant and inhibitor of PTP1B enzyme, but not been fully elucidated. Licochalcone C was synthesized from commercially available 2,4-dihydroxybenzaldehde by using regioselective Al2O3-mediated C-prenylation followed by conventional Claisen-Schmidt condensation in basic condition. Direct water-accelerated [3,3]-sigmatropic rearrangement reaction of chalcones could not be employed in the licochalcone C synthesis due to the decomposition problems, however we found the regioselective C-prenylation using Al2O3 for a new additional licochalcone C synthesis.

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