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  • 02월 20일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제113회 대한화학회 학술발표회, 총회 및 기기전시회 안내 A New Approach to the Synthesis of N-Arylcarbamates

등록일
2014년 2월 13일 16시 12분 50초
접수번호
1090
발표코드
ORGN.P-781 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 16일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
문수연, KIMUBIN, 김원석*
이화여자대학교 화학 나노과학과, Korea

N-Arylcarbamate moiety is widely encountered in the structure of biologically active compounds. They are also valuable synthetic intermediates and are widely used for the synthesis of drug, urea derivatives and as protecting groups of amines in peptide synthesis. Even though these compounds are generally prepared from phosgene, phosgene derivatives or isocyanates in the presence of alcohols, these methods are not environmentally benign due to the use of toxic reagents and generation of by-products. Thus, various methods have been developed to synthesize N-arylcarbamates to avoid such drawbacks. Herein, we report a new approach to the synthesis of N-arylcarbamates employing boronic acids and azidoformate in an open flask at room temperature without any base, ligand, or additive. Various N-arylcarbamates were prepared with differing substitution and functional groups on both coupling partners to illustrate scope and tolerance of this mild and efficient methodology.


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