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  • 02월 20일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제113회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Identification of Anti-oxidative, Whitening and Anti-inflammatory Constituents from Oreocnide fruticosa Branches

2014년 2월 13일 16시 47분 29초
MEDI.P-891 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 16일 (수요일) 16:00~19:00
저자 및
한정환, 김형민, 강승협, 문승리, 한미경, 변상희, 이남호*
제주대학교 화학과, Korea
In this study anti-oxidative, whitening and anti-inflammatory activities were examined on the extract from Oreocnide fruticosa branches and their biologically active constituents were identified. From repeated fractionation procedures, 7 compounds were isolated from Oreocnide fruticosa branches; friedelin (1), friedelanol (2), 5,7-dihydroxychromone (3), methyl vanillate (4), catechin (5), epi-catechin (6) and scopoletin (7). The structures of these compounds were confirmed by comparing their spectroscopic data to those in the literature. All of these compounds (1-7) were isolated for the first time from O. fruticosa. The isolated compounds were examined for anti-oxidative, whitening and anti-inflammatory activities. For the anti-oxidative activity test, the compounds 5 and 6 showed good DPPH radical scavenging activities with SC50 of 40.05 and 29.92 μM respectively, whose activities were comparable to a positive control vitamin C (SC50 46.23 μM). In addition, compounds 5, 6 and 7 showed good ABTS radical cation scavenging activity with SC50 of 7.56, 7.21, 64.04 μM respectively, showing comparable activity to vitamin C (SC50 31.32 μM). On the tyrosinase inhibition activity test, the compound 7 showed good inhibitory activity with IC50 111.80 μM, whose activities were more potent than a positive control arbutin (IC50 209.68 μM). For the anti-inflammatory activity test, the compound 7 showed inhibitory activity with 48.5% at 300 μM, without showing any cytotoxicity. Based on these results, O. fruticosa branches extract could be potentially applicable as cosmeceutical ingredient.