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학술발표회초록보기

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  • 02월 20일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제113회 대한화학회 학술발표회, 총회 및 기기전시회 안내 The role of the water in synthesis of benzimidazoles via metal-free aerobic oxidation

등록일
2014년 2월 13일 16시 53분 20초
접수번호
1186
발표코드
ORGN.P-796 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 16일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
이예솔, 천철홍*
고려대학교 화학과, Korea
Benzimidazoles are common building blocks found in biologically and therapeutically active compounds, natural products and material science. Thus, the development of efficient synthetic methods to access these important compounds has been extensively investigated. One of the conventional methods for the synthesis benzimidazoles is oxidative cyclization which is starting from o-phenylenediamine and aldehyde through imine intermediates in presence of strong oxidants. Recently we have developed the novel one-pot protocol via metal-free aerobic oxidation. During this investigation, we found that water is the key factor of oxidative cyclization. Based on this finding, we have developed highly environmental benign protocol for the synthesis of benzimidazoles in either wet organic solvents or protic solvents. In addition, this protocol can be extended to the synthesis of benzimidazoles bearing oxidation-labile functional group such as boronic acid.

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