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  • 02월 20일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제113회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Further Optimization of Matrix-Assisted Laser Desorption/Ionization for Gangliosides

등록일
2014년 2월 17일 13시 23분 41초
접수번호
1244
발표코드
ANAL.P-523 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 16일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
분석화학
저자 및
공동저자
이동건, 차상원*
한국외국어대학교 화학과, Korea
Gangliosides, glycosphingolipids with one or more sialic acids, are one of the lipids which undergo severe in-source fragmentation during matrix-assisted laser desorption/ionization (MALDI) process. We previously reported that 5-methoxysalicylic acid (5-MSA) is the very effective matrix for gangliosides since minimal in-source fragmentation of gangliosides was observed with the 5-MSA matrix. In this study, we further investigated the LDI performance of 5-MSA by comparing its property with those of its isomers and several known conventional MALDI matrixes. In addition, we optimized ionization of gangliosides by employing various salt additive conditions. Our results showed that cationization of gangliosides through cesium ions in the positive ion modes have several advantages over other salt additives. First, heavy cesium ions spread mass spectral profiles of gangliosides over wider m/z ranges and therefore reduced spectral complexity. Second, cesium adduct ions gave the better sensitivity than other adduct ions.

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