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학술발표회초록보기

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  • 02월 20일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제113회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Ratiometric method for bio analysis using magnetic nanoparticles (MNPs) in ICP-MS

등록일
2014년 2월 17일 16시 31분 45초
접수번호
1251
발표코드
ANAL1-3 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 10시 : 10분
발표형식
심포지엄
발표분야
분석화학 - Advanced Bio and Environmental Analysis I: Sensor and Chip
저자 및
공동저자
임흥빈
단국대학교 화학과, Korea
When various bio targets in the range of small molecules like antibiotics to large cells were analyzed using nanoparticles, sample treatment procedure was the most critical point for practical application. In this presentation, we introduced a ratiometric technique to improve the analytical performance of both treatment platforms, i.e., sandwich-type and non-specific extraction immunoreaction. In order to achive this purpose, various magnetic nanoparticles doped with various metals were synthesized for the extraction of the targets. Then the synthesized nanoparticles were used for magnetic separation to extract biomarkers and the doped metal was used as an internal standard for the ratiometric measurement of the tagged particle. This ratiometric method compensated for the particle loss in a magnetic separation and suppressed the signal fluctuation which increased the calibration linearity significantly. The developed analytical method improved analytical figures-of-merits when targets were determined by ICP-MS.

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