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  • 02월 20일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제113회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Highly Enantioselective Extraction of Underivatized Amino Acids by the Uryl-Pendant Hydroxyphenyl-Binol Ketone

등록일
2014년 2월 18일 17시 10분 05초
접수번호
1268
발표코드
ORGN.P-808 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 16일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
ChenQian, 김관묵1,*
이화여자대학교 화학나노과학과, Korea
1이화여자대학교 화학과, Korea
Pure enantiomeric amino acids attracted significant interests because they are widely used in basic peptide and pharmaceutical industries. Enantioselective liquid-liquid extraction (ELLE) is one of promising extraction processes applied in the chiral resolution of amino acids. This method has great advantages in industrial application due to low energy consumption, continuous recycling and easy scaling up. Here our group successfully synthesized the hydroxyphenyl chiral ketone, which shows high selectivities as a chiral extractant in the ELLE for general underivatized amino acids. The multiple hydrogen bonds formed in the imine of the ketone with an amino acid reinforce the rigidity, and result in the different stability between the imine diastereomers. The amino acids obtained after the hydrolysis of the imine in methanol have enantiomeric excess (ee) values of over 97%. The ketone could have been perfectly recycled and entered into a new extraction cycle.

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