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학술발표회초록보기

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  • 02월 20일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제113회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis and Biological Evaluation of Furomollugin and Its Analogues

등록일
2014년 2월 18일 21시 05분 24초
접수번호
1276
발표코드
ORGN.P-809 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 16일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
CAIHONGYUN, 하립개, 이용록1,*
영남대학교 화학공학부, China
1영남대학교 화학공학부, Korea

Diverse furomollugin (3) and its analogues (11 - 22) were synthesized in high yields via CAN-catalyzed formal [3+2] cycloaddition as a key step. The in vitro antioxidant activities of synthesized compounds were determined by analyzing radical scavenging activities for 1,1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide (NO), and hydrogen peroxide (H2O2) assays. The results showed that the synthesized furomollugin analogues had effective antioxidant power. Dihydronaphthofurans with 2-alkyoxy or 2-aryl group were the most potent radical scavengers in DPPH assay. Moreover, the antibacterial activities of those compounds were also evaluated and the highly active compounds were selected for further determination of minimal inhibitory concentrations (MICs). Compound 19 (MIC = 2 μg/mL) was found to be highly active against the gram-negative bacteria E. coli (KCTC-1924) than the Ampicillin standard (MIC = 4 μg/mL). Compound 22 (MIC = 0.5 μg/mL) inhibited gram-positive bacteria S. aureus (KCTC-1916) growth as effectively as Ampicillin (MIC = 0.5 μg/mL).


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