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  • 02월 20일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제113회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Medical Application of Zr-89 Oxalate for PET Radiopharmaceutical

2014년 2월 19일 17시 10분 30초
MEDI.P-897 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 16일 (수요일) 16:00~19:00
저자 및
이지웅, 박지애1, 신운철2, 이교철3, 안광일4,*, 김정영3,*
고려대학교 보건과학, Korea
1한국원자력의학원 분자영상연구부 핵의학연구팀, Korea
2연세대학교 의공학과, Korea
3한국원자력의학원 방사성의약품연구팀, Korea
4한국원자력의학원 방사성의약품 개발실, Korea

Objective: Positron-emitted Zr-89 (Zirconium, half-life 3.27 days) in clinic has recently been reported to be particularly effective at PET imaging. Such Zr-89 depends on a good bifunctional chelator and proper biomolecule (peptides, antibody, etc.) for specific binding in cell. The aim of our study, thus, was to widen the use of Zr-89 in Korean clinic with development of PET technology. Material & Method: Zr-89 was generated by nuclear reaction of 50 MeV cyclotron (Scantronix co.) in KIRAMS, which was used as target material of yttrium foil. The nuclear reaction was carried out Y-89(p,n)Zr-89 under irradiation of proton beam (20 μA, 18 MeV) for 2 hours. The purification of Zr-89 was performed with a specific Sep-PaK column (hydroxamate resin). On this column, Zr-89 oxalate was rapidly prepared as high radiochemical purity. Result: Zr-89 oxalate was easily prepared by short column, and the radiochemical purity was over 99%. The radiochemical yield of product was obtained as radioactive solution of 9-13 mCi in hydrochloric acid (1 mL, 1 M). Zr-89 was showed the specific gamma-energy of both 511 and 909 KeV as reported previously. Zr-89 oxalate, thus, was successfully exhibited good PET imaging of bone marrow in mouse. Zr-89 was further studied the ability of PET imaging using phantom and microPET scanner. Conclusion: The development of Zr-89 oxalate may be extended to the studies of new radiotracer for PET molecular imaging.