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학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

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  • 02월 20일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제113회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis of glycocluster synthesis for studies of functional glycomics

등록일
2014년 2월 20일 16시 30분 47초
접수번호
1407
발표코드
ORGN.P-842 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 16일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
배재영, 신인재*
연세대학교 화학과, Korea

Glycans, which are found mainly in the form of glycoconjugates such as glycoproteins, proteoglycans, and glycolipids inside or on the surface of cells, participate in a wide range of physiological and pathological processes through interactions with proteins. It is generally accepted that multivalent interactions between glycans and proteins enhance an otherwise weak binding affinity of monomeric sugars with receptors. Enhancements in binding affinity by multivalent interactions (often referred to as the cluster glycoside effect) are attributed to the chelate effect, clustering of carbohydrate-binding proteins, or statistical rebinding. To readily obtain glycoclusters with diverse spatial separation and various valences of sugars, we have developed an efficient solid-phase synthetic strategy for peptide-based glycoclusters. By using this methodology, various glycoclusters with a valence ranging from 1 to 4 and different spatial arrangements of the sugar ligands were prepared. And we used these glycoclusters for studies of functional glycomics.


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