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  • 02월 20일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제113회 대한화학회 학술발표회, 총회 및 기기전시회 안내 DNA-Modified Au Core and Au Shell Nanoparticle for Highly Sensitive and Stable SPECT Imaging Probe

2014년 2월 20일 16시 35분 16초
MAT.P-1082 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 16일 (수요일) 16:00~19:00
저자 및
이상봉, KumarDinesh1, 김수민, 국현2, 임동권*
전북대학교 BIN 융합공학과, Korea
1Chonbuk National Uni BIN Fusion Tech., Korea
2전북대학교 BIN융합공학과, Korea

Abstract: The radio-isotope labelled biomolecules (i.e., peptide, protein) have been widely used as in-vivo imaging probe, but suffer from fast excretion, off-target effect, and lack of biological stability. It has been known that the use of nanoparticle can alter the pharmacokinetics and pharmacodynamics of conventional drug molecules. In this regards, nano-sized imaging probe with high sensitivity and excellent biological stability was greatly demanded. Here, we report highly sensitive and stable SPECT imaging probe by use of simple chemistry of sodium iodide (125) and adenine-rich oligonucleotide modified AuNP, and seed-mediated Au shell growth in solution. In theory, two thousands of Iodine-125 can be covalently conjugated to DNA base per gold nanoparticle (20 nm), which can greatly increase the radio sensitivity of nanoparticle. Iodine-125 embedded Au@Au nanostructure was synthesized by forming uniform Au shell with 10 nm thickness, which can improve the stability of Iodine-125 label on gold nanoparticle by preventing possible hydrolysis or enzymatic attacks in in-vivo. Three different diameter of Iodine-125 embedded Au@Au nanostructure (27, 32, 42 nm) were prepared to investigate radio sensitivity, biological stability, and in-vivo distributions for efficient SPECT imaging. A series of analysis showed highly sensitive radio activity, increased stability of Au@Au nanostructure, and size-dependent particle distributions in normal mice.