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학술발표회초록보기

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  • 02월 20일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제113회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Sphingolipid metabolism in cardiovascular and metabolic disease

등록일
2014년 2월 21일 14시 32분 33초
접수번호
1424
발표코드
BIO1-4 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 10시 : 20분
발표형식
심포지엄
발표분야
생명화학 - Lipid and Glycochemistry
저자 및
공동저자
박태식
가천대학교 글로벌캠퍼스 생명과학과, Korea
Overnutrition and sendentary lifestyle cause obesity in human. Ectopic accumulation of lipids in peripheral tissues and elevated free fatty acids are major causes of metabolic dysfunction. Lipotoxicity that accumulation of bioactive lipid metabolites disrupts the tissue function has been suggested for development of cardiovascular disease. Among them, ceramide has drawn attentions as a risk factor of cardiovascular and metabolic disease. Elevated ceramide derived from increased plasma free fatty acid leads to inhibition of insulin response, formation of atherosclerotic plaques, cardiomyopathy, and vascular dysfunction. Clinical studies have reported a positive correlation between ceramide/sphingomyelin and coronary artery disease. Intervention by pharmacological and genetic methods demonstrated that modulation of sphingolipid biosynthesis is a therapeutic target for these chronic diseases. The results obtained from animal models and pharmacological modulation elucidate the mechanism of alleviated cardiovascular dysfunction by reduced ceramide/sphingomyelin. Recent findings demonstrated that reduced ceramide improves vascular dysfunction caused by obesity via PP2A-mediated dephosphorylation of eNOS and reduced nitric oxide bioavailability. These results and those obtained from other disease models suggest that modulation of sphingolipids is a novel therapeutic method to prevent cardiovascular and metabolic dysfunction.

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