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제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Forensic applications of mass spectrometry for illicit drug testing

2014년 8월 26일 19시 03분 40초
ANAL1-5 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 11시 : 20분
분석화학 - Analytical Chemistry for Environmental & Forensic Sciences
저자 및
대검찰청 과학수사담당관실, Korea
Forensic toxicology deals with hundreds of drugs that are abused or illicit. These compounds should be rapidly and reliably detected and identified in biological samples on a routine analysis. Combined chromatography-mass spectrometric techniques have been most commonly used for this purpose. GC-MS has been considered as the ‘gold standard’ for forensic compound identification, while LC-MS has become an increasingly important technique due to its usefulness for the analysis of hydrophilic, thermolabile, and non-volatile compounds. The hemp plant Cannabis sativa is one of the most widely abused illicit substances in Korea. However the incorporation of THC-COOH into hair is very small, making quantification challenging due to the very high sensitivity required. The proposed cut-off concentration for the detection of THC-COOH in hair is 0.2 pg/mg from the Society of Hair Testing and 0.05 pg/mg under the federal regulations of the United States. To satisfy these analytical requirements, we have focused on GC-MS/MS methods for the determination of THCCOOH in hair. The developed method provided reliable data for use in forensic toxicology and results in a substantial increase in detection sensitivity by the combination of GC, NCI and MS/MS.