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학술발표회초록보기

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제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Forensic applications of mass spectrometry for illicit drug testing

등록일
2014년 8월 26일 19시 03분 40초
접수번호
0321
발표코드
ANAL1-5 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 11시 : 20분
발표형식
심포지엄
발표분야
분석화학 - Analytical Chemistry for Environmental & Forensic Sciences
저자 및
공동저자
김진영
대검찰청 과학수사담당관실, Korea
Forensic toxicology deals with hundreds of drugs that are abused or illicit. These compounds should be rapidly and reliably detected and identified in biological samples on a routine analysis. Combined chromatography-mass spectrometric techniques have been most commonly used for this purpose. GC-MS has been considered as the ‘gold standard’ for forensic compound identification, while LC-MS has become an increasingly important technique due to its usefulness for the analysis of hydrophilic, thermolabile, and non-volatile compounds. The hemp plant Cannabis sativa is one of the most widely abused illicit substances in Korea. However the incorporation of THC-COOH into hair is very small, making quantification challenging due to the very high sensitivity required. The proposed cut-off concentration for the detection of THC-COOH in hair is 0.2 pg/mg from the Society of Hair Testing and 0.05 pg/mg under the federal regulations of the United States. To satisfy these analytical requirements, we have focused on GC-MS/MS methods for the determination of THCCOOH in hair. The developed method provided reliable data for use in forensic toxicology and results in a substantial increase in detection sensitivity by the combination of GC, NCI and MS/MS.

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