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제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 An electrochemical, straightforward HbA1C biosensor via use of electrochemically active nanoprobes

등록일
2014년 8월 28일 16시 30분 47초
접수번호
1249
발표코드
ELEC.P-1241 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
전기화학
저자 및
공동저자
심승은, 이정봉, 현혜리, 양현희, 권지윤, 차근식, 남학현, 신재호*
광운대학교 화학과, Korea
Diabetes mellitus, which is characterized by the defective regulation of blood glucose, is one of the major health concerns worldwide. The diagnosis and management of this disease require continuous monitoring of blood glucose level. However, glucose level is influenced by food or exercise and hence does not reflect the average glucose level over a prolonged period. To overcome such drawbacks, glycosylated hemoglobin (HbA1C) presents a promising marker for performing long-term diabetes monitoring. HbA1C is formed by non-enzymatic glycosylation of hemoglobin when it was exposed to higher than normal level of blood glucose over time. The level of HbA1C reflects the average of the blood glucose concentration over the preceding 2-3 months. Herein we report a new concept of an electrochemical biosensor for the detection of HbA1C by using a specific reaction of HbA1C with boronic acids. Of note, the binding of HbA1C to boronic acids immobilized on the electrode surface may lead to change the electrochemical signal by blocking the access of redox probes. To emphasize such blocking effect, nanoparticular probes such as ferrocene (Fc)-modified silica nanoparticles will be employed. Furthermore, various types of boronic acid derivatives which are able to form self-assembled monolayer on gold electrode, have been studied to improve sensor performance (e.g., sensitivity, detection limit, and linear response range). In addition, the effect of pH was also investigated as it influences the formation of complex between boronic acids and HbA1C. Finally, the optimized sensors will be employed to determine HbA1C concentrations in physiological specimen.

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