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학술발표회초록보기

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  • 09월 04일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 New naphthalimide derivative for detection hydrogen peroxide in living cells

등록일
2014년 8월 28일 16시 31분 42초
접수번호
1253
발표코드
ORGN.P-869 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
김진아, 김다빈1, 윤주영2,*
이화여자대학교 유기화학, Korea
1이화여자대학교 화학.나노과학과, Korea
2이화여자대학교 화학·나노과학과, Korea

Reactive oxygen species (ROS) play an essential role in many biological processes such as aging and immunity. However, deregulation of ROS production and/or elimination may cause pathophysiological consequences such as aging and chronic inflammatory diseases of the human. Many efforts have been focused on developing selective fluorescent probes to image ROS including H2O2. In the chemical, biological, environmental and medical sciences, detection of hydrogen peroxide (H2O2) is important. Hydrogen peroxide (H2O2) enables lysosome to detect. The cause of disease such as cancer, cardiovascular diseases and storage disorders is related to the lysosome. So, it is important to detect and image the lysosome for understanding of intracellular reaction and mechanisms.Therefore, we designed and synthesized a fluorescent probe for hydrogen peroxide (H2O2) with high sensitivity and selectivity for detection of lysosome. A new probe based on naphthalimide. When hydrogen peroxide was added to 1, probe 1 was converted to 2 and showed fluorescence. This phenomenon easily monitored in live cells. References 1. Q. Xu, K. Lee, S. Lee, K. Lee, W. Lee, J. Yoon, J. Am. Chem. Soc. 2013, 135, 9944-9949 2. Q. Qiao, M. Zhao, H. Lang, D. Mao, J. Cui, Z. Xu, RSC Adv., 2014, 4, 25790-25794 3. O. S. Wolfbeis, A. Durkop, M. Wu, Z. Lin, Angew. Chem. Int. Ed. 2002, 41, 4495-4498


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