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Reactive oxygen species (ROS) play an essential role in many biological processes such as aging and immunity. However, deregulation of ROS production and/or elimination may cause pathophysiological consequences such as aging and chronic inflammatory diseases of the human. Many efforts have been focused on developing selective fluorescent probes to image ROS including H2O2.
In the chemical, biological, environmental and medical sciences, detection of hydrogen peroxide (H2O2) is important. Hydrogen peroxide (H2O2) enables lysosome to detect. The cause of disease such as cancer, cardiovascular diseases and storage disorders is related to the lysosome. So, it is important to detect and image the lysosome for understanding of intracellular reaction and mechanisms.Therefore, we designed and synthesized a fluorescent probe for hydrogen peroxide (H2O2) with high sensitivity and selectivity for detection of lysosome.
A new probe based on naphthalimide. When hydrogen peroxide was added to 1, probe 1 was converted to 2 and showed fluorescence. This phenomenon easily monitored in live cells.
References
1. Q. Xu, K. Lee, S. Lee, K. Lee, W. Lee, J. Yoon, J. Am. Chem. Soc. 2013, 135, 9944-9949
2. Q. Qiao, M. Zhao, H. Lang, D. Mao, J. Cui, Z. Xu, RSC Adv., 2014, 4, 25790-25794
3. O. S. Wolfbeis, A. Durkop, M. Wu, Z. Lin, Angew. Chem. Int. Ed. 2002, 41, 4495-4498
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