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제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Detection of peroxynitrite in a ratiometric and colorimetric manner with high sensitivity and selectivity by using a CHCN probe

등록일
2014년 8월 28일 16시 31분 44초
접수번호
1254
발표코드
ORGN.P-870 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
백연주, zhouxin1, 윤주영2,*
이화여자대학교 유기화학, Korea
1이화여자대학교 화학나노과학과, Korea
2이화여자대학교 화학·나노과학과, Korea

Peroxynitrite has a multiple physiological and pathological roles in cellular signaling transduction and cell damage. Therefore, the interest in developing fluorescent probe for selective detection of this reactive oxygen species has been increased these days. The red emitting probe CHCN can dedect ONOO- and CHCN is dissapeared in the presence of ONOO- and be replaced by green emission. ONOO- produced by an oxidation process reacts with CHCN and shows a dual ratiometric and colorimetric response. CHCN has appreciable cell permeability and, as a result, it is applicable to ratiometric detection of exogenous and endogenous ONOO- in living cells during phagocytic immune response. Therefore, We anticipate that, owing to their ideal properties, we can look cell imaging easily and this type of probe will find great use in explorations of the role played by ONOO- in biology. References 1. Guo, Z., Park, S., Yoon, J., Shin, I., 2014. Recent progress in the development of near-infrared fluorescent probes for bioimaging applications. Chem Soc Rev 43(1), 16-29. 2. Xu, Q., Lee, K.A., Lee, S., Lee, K.M., Lee, W.J., Yoon, J., 2013. A Highly Specific Fluorescent Probe for Hypochlorous Acid and Its Application in Imaging Microbe-Induced HOCl Production. Journal of the American Chemical Society 135(26), 9944-9949.


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