Two unique pyrene derivatives (1 and 2) are reported as Zn2+ selective fluorescent probes, in which two pyrenes bearing imine and OH groups are connected via ether linker (1) or thioether linker (2). Upon the addition of Zn2+, resulting phenolate group can induce internal charge transfer (ICT) peaks, which can cause selective turn-on fluorescence of 1 and 2 at 550 nm. Probes 1 and 2 can successfully image exogenous Zn2+ ions as well as free zinc ions released during apoptosis. Also we developed sensor 3-Cu (II) for detection of GSH, Complex 3-Cu (II) senses GSH and give a marked fluorescence enhancement at pH 7.4 under aqueous media.
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