abs

학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 09월 04일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Applications of paper spray ionization mass spectrometry in the studies of host-guest chemistry and steroid analysis

등록일
2014년 8월 28일 16시 55분 51초
접수번호
1331
발표코드
ANAL.P-577 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
분석화학
저자 및
공동저자
김푸름, 전규웅, 차상원*
한국외국어대학교 화학과, Korea
Paper spray ionization (PSI) method is one of the ambient ionization techniques for mass spectrometry (MS). PSI utilizes a triangular shape filer paper as a sampling base as well as an electrospray tip. PSI MS has been demonstrated as a promising tool for fast chemical screening, drug monitoring, and complex mixture fingerprinting. In this study, we applied PSI MS to understand host-guest chemistry. One of the model systems we used were complexes of cholesterol derivatives and cyclodextrins. From a series of experiments, we found that PSI MS was a very useful tool for determining binding preferences and affinities between various host and guest molecules in a very short period of time. In addition, we also performed analyses of nonderivatized sex hormones by using a homebuilt PSI MS system. We enhanced the detectability of the nonderivatized steroid ions and signal reproducibility through the optimization of the spraying solvents. After optimization, we could perform fast and reliable quantitative analyses of sex hormones which can be potentially used as a clinical screening tool for sex hormones.

상단으로