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학술발표회초록보기

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  • 09월 04일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Elucidation of Binuclear Non-Heme Iron Enzyme Intermediates

등록일
2014년 9월 1일 19시 57분 49초
접수번호
1409
발표코드
INOR.O-3 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 10시 : 40분
발표형식
구두발표
발표분야
무기화학 - Oral Presentation for Young Inorganic Chemists
저자 및
공동저자
박기영
한국과학기술원(KAIST) 화학과, Korea
Binuclear non-heme iron enzymes perform a wide range of chemistries that are essential for aerobic metabolism. This class of enzymes utilizes a coupled diiron cofactor to activate O2 to form peroxy or high-valent oxygen intermediates that lead to H-atom abstraction, desaturation, hydroxylation, or electrophilic attack. To understand this diverse reactivity of the diiron cofactor, various spectroscopic techniques, such as nuclear resonance vibrational spectroscopy, circular dichroism (CD), magnetic CD (MCD), variable-temperature, variable-field MCD, and resonance Raman spectroscopies, and density functional theory computations have been applied to define key oxygen intermediates. Specifically, two peroxy intermediates, only one of which is poised for O-O bond cleavage, have been structurally defined, and their differences in spectroscopic properties and electrophilic reactivity have been clarified. This understanding of the peroxy-level intermediates is key to elucidating the mechanisms of class Ia ribonucleotide reductase (RR) and soluble methane monooxygenase (MMO), where the peroxy intermediates further convert to reactive high-valent intermediates that abstract an H atom from Tyr in RR and from CH4 in MMO.

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