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학술발표회초록보기

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  • 09월 04일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Green Sample Preparation for Determination of NSAIDs by HPLC

등록일
2014년 9월 2일 09시 53분 22초
접수번호
1410
발표코드
ANAL.P-580 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
분석화학
저자 및
공동저자
박소연, 조현우1, 명승운*
경기대학교 화학과, Korea
1경기대학교 자연과학화학과, Korea
Dispersive liquid-liquid microextraction ( DLLME ) may be utilized as a green chemistry approach to reduce the consumption of hazardous organic solvents in the chemical analysis. A simple and efficient sample preparation method was developed using DLLME prior to HPLC/UV analysis for simultaneous extraction and determination of trace amounts of Non-Steroidial Anti-Inflammatory Drugs (NSAIDs) including indoprofen, ketoprofen, naproxen, diclofenac, ibuprofen, mefenamic acid, tolfenamic acid from an aqueous sample. Optimal dispersive solvent and extraction solvent were chosen acetonitrile and chloroform, respectively, and showed increased enrichment factor (EF = 9~18) for the extraction of NSAIDs. Simultaneous chromatographic separation of seven NSAIDs by HPLC-UV/Vis system was achieved on an Eclipse XDB-C18 (4.6 mm i.d. × 150 mm length, 5 ㎛ particle size) column using isocratic elution with 0.1 % formic acid and methanol (30 :70). NSAIDs were extracted and concentrated from 5 mL of aqueous solution with pH 3.8. The volume of dispersive and extraction solvent were 1000 ㎕ and 200 ㎕, respectively. After the extraction, 5 ㎕ of extract was directly injected into the HPLC/UV system. The developed method represents a simple, rapid, environmentally friendly and inexpensive sample preparation method.

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