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학술발표회초록보기

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  • 09월 04일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Catalytic Enantioselective C-H and C-C Insertion Reactions with Diazoesters

등록일
2014년 9월 3일 12시 35분 26초
접수번호
1433
발표코드
ORGN2-6 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 15시 : 50분
발표형식
분과기념
발표분야
유기화학 - Current Trends in Organic Chemistry II: Metallo-Organic Reaction
저자 및
공동저자
류도현
성균관대학교 화학과, Korea

The chemistry of α-diazocarbonyl compounds has attracted great attention because of its extensive applications in organic chemistry since the first recorded synthesis of ethyl diazoacetate by Curtius in 1883. Recently, we developed highly enantioselective, catalytic cyclopropanation with diazoesters in the presence of chiral oxazaborolidinium ion in high yield (up to 93%) with high to excellent diastereoselectivity (up to 98% de) and enantioselectivity (up to 95% ee). In this talk, we will present that highly enantioselective Carbon-Hydrogen and Carbon-Carbon insertion reactions with diazoesters. Theses methodologies were successfully applied to the synthesis of the natural products, sitophilate, and (+)-epijuvabione. As another application, optically active quaternary α- and β-amino esters were prepared from all carbon α-quaternary aldehydes in good yields and excellent enantioselectivities.


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