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학술발표회초록보기

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  • 09월 04일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Alleviation of capsular formation on the silicone implant inserted in rats by biomembrane-mimic coating

등록일
2014년 9월 4일 15시 01분 02초
접수번호
1481
발표코드
BIO.P-655 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
함지연, 이연1,*
서울대학교 자연과학대학 화학부, Korea
1서울대학교 화학부, Korea

Silicone implants are popularly used in breast augmentation and reconstruction surgeries, but limited biocompatibility induces severe side effects such as capsular contracture, an excessive foreign body reaction forming a tight and hard fibrous capsule around the implant. This study examined the effects of biomembrane-mimic surface coating of silicone implants to the capsular formation. Covalently attached biomembrane-mimic polymer, poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), prevented nonspecific protein adsorption and fibroblast adhesion on the silicone surface. More importantly, in vivo capsule formation around the PMPC-grafted silicone implant in rats represented significantly thinner capsules, lower collagen density, and more regular collagen alignment than bare silicone implant. The decrease of α-smooth muscle actin also supported the alleviation of capsular formation by the biomembrane-mimic coating. Decrease of inflammation-related cells, myeloperoxidase, and transforming growth factor-β showed reduced inflammation in the capsular tissue. The biomembrane-mimic coating of silicone implants will have a high potential to prevent capsular contracture and to develop biocompatible materials for various biomedical applications.


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