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  • 09월 04일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 A Medusa-Like β-cyclodextrin with Maleic Anhydride Derivatives, A Potential Carrier for pH-Sensitive Drug Release

2014년 9월 4일 15시 04분 39초
BIO.P-657 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 15일 (수요일) 16:00~19:00
저자 및
박으뜸, 이연1,*
서울대학교 화학과, Korea
1서울대학교 화학부, Korea
We developed a new pH-sensitive drug delivery carrier based on β-cyclodextrin (β-CD) and 1-methyl- 2-(2'-carboxyethyl) maleic anhydrides (MCM). To optimize pH-sensitivity for controlled drug release, we synthesized five maleic acid amide derivatives (maleic, citraconic, cis-aconitic, 2-(2’-carboxyethyl) maleic, MCM) maleic acid amide), and compared their degradability for the development of pH-sensitive biomaterials with tailored kinetics of the release of drugs. Based on these results, we selected MCM and the primary hydroxyl groups of β-CD were successfully attached to MCM residues to produce a medusa-like β-CD-MCM. The MCM residue was conjugated with cephradine (CP) with high efficiency (>90%). More importantly, β-CD-MCM-CP responded to the small pH drop from 7.4 to 5.5 and released greater than 80% of the drugs within 0.5 h at pH 5.5. In addition, the inclusion complex between β-CD-MCM-CP and the adamantane derivative was formed by simple mixing to show the possibility of introducing multi-functionality. Based on these results, β-CD-MCM can target weakly acidic tissues or organelles, such as tumours, inflammatory tissues, abscesses, or endosomes, and be easily modified with various functional moieties, such as ligands for cell binding or penetration, enabling more efficient and specific drug delivery.