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학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

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  • 09월 04일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Target Specific Imaging of Cancer Cells Using The Biotin-Indocyanine Green (Biotin-ICG) Conjugate

등록일
2014년 9월 4일 15시 55분 20초
접수번호
1503
발표코드
ORGN.P-907 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
엄수진, 김종승*, 정효성, 권보미, 박소연, 김원영
고려대학교 화학과, Korea

In clinical practice, the major method to treat cancer is surgical resection. In that sense, precise spatial discrimination between cancer and healthy tissue is the main issue. To reach this goal, image guided cancer surgery using near-infrared (NIR) fluorescence has emerged as attractive approach. Among NIR fluorophores, which provide advantages of improved contrast and deep tissue penetration, only indocyanine green (ICG) is approved by FDA for clinical use. However, ICG is limited by a lack of target specificity. Herein, we present the design, synthesis and contrast efficacy of a novel tumor targeted NIR contrast agent, Biotin-Indocyanine green (Biotin-ICG), which can specifically target the cancer cell. The intracellular uptake experiments prove that the targeting efficacy of the Biotin-ICG was more effective than that of free ICG in biotin receptor-positive HeLa tumor cells. Furthermore, the results from cell viability tests also confirm that Biotin-ICG did not show any cytotoxicity. Therefore, Biotin-ICG is expected to be a suitable contrast agent for surgical image guidance.


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