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  • 09월 04일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Au Nanowire SERS Platform for Telomerase Activity Detection

등록일
2014년 9월 4일 16시 06분 33초
접수번호
1508
발표코드
ANAL.P-594 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
분석화학
저자 및
공동저자
엄가영, 김홍기1, 강태준2,*, 김봉수*
한국과학기술원(KAIST) 화학과, Korea
1한국과학기술원(KAIST) 화학, Korea
2한국생명공학연구원(KRIBB) 바이오나노연구센터, Korea
Human telomere acts as biological clock, consisting of TTA GGG repeats at the end of the chromosomes. During cell division, this telomere is shortened, which can cause the fusion with neighboring chromosomes. However, telomerase replenish shortened telomere by adding telomeric repeats (TTA GGG)n. Due to the high expression level of telomerase in tumor cells, telomerase is an attractive tumor biomarker and a potential target for cancer therapy. Developing the robust sensor platform for the measurement of telomerase activity is desired in cancer diagnosis and therapy. Many researchers have explored the newly designed sensor for sensitive and reproducible telomerase activity detection. Especially, surface-enhanced Raman scattering (SERS) has been considered as a highly sensitive and robust optical analysis technique for biomolecule detection. Herein, we fabricated noble metal nanowire SERS platform for telomerase activity detection. An ultrasensitive and highly-reproducible sensing was possible by using our novel SERS platform. We anticipate that our SERS sensor has the great potential in practical cancer diagnosis.

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