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학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

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  • 09월 04일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Lipidomics Platform to Find the Lipid Alteration in Biological Samples

등록일
2014년 9월 4일 16시 43분 59초
접수번호
1520
발표코드
ANAL2-4 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 15시 : 00분
발표형식
심포지엄
발표분야
분석화학 - Recent Developments in Chemical Analysis Methods
저자 및
공동저자
김광표
경희대학교 응용화학과, Korea
Lipidomics is a systems-level analysis of lipid species, their abundance, biological activities, and subcellular localization. Many studies have reported the aberrant lipid metabolism in human disease. Thus, there are increasing interests in finding the lipid alteration between disease samples and controls. In lipidomics, it is critical to construct a well-designed platform to identify the differentially expressed lipids (DELs) in biological samples. First, we need an exhaustive lipid profiling method. Second, a robust statistical analysis of lipid profiles is required for the reliable data analysis. We described here an established lipidomics platform that consists of global lipid profiling based on LC/Qof MS and lipid quantification based on by LC/QqQ MS. High accuracy mass analysis was effective to profile various lipid, and multiple reaction monitoring was useful to sensitive and selective quantification. This platform was applied to the biological sample analysis, and its utility was demonstrated.

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