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  • 09월 04일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Enantioselective Alkynylation of Trifluoromethyl Ketones Catalyzed by Functionalized-Salen Ni Complexes

등록일
2014년 9월 11일 16시 09분 03초
접수번호
1536
발표코드
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발표시간
목 14시 : 40분
발표형식
심포지엄
발표분야
유기화학 - Current Trends in Organic Chemistry II: Metallo-Organic Reaction
저자 및
공동저자
홍석원
광주과학기술원(GIST) 신소재공학부, Korea
Cooperative catalysis has emerged as a powerful strategy in catalytic asymmetric synthesis. As a part of our program aiming at asymmetric cooperative catalysts, we have developed a series of functionalized salen transition metal catalysts to facilitate challenging bimetallic reactions through the H-bond mediated self-assembly. Recently we also reported that the urea-functionalized-salen Co catalysts could provide an alternative bifunctional activation of an anionic nucleophile (by H-bond) and an aldehyde (by Lewis acid metal center). Herein we wish to report that novel functionalized-salen Ni complexes are highly efficient catalysts for the enantioselective direct alkynylation of trifluoromethyl ketones, affording enantioenriched propargyl alcohol products in high yields and enantioselectivities. The current methodology is operationally simple and allow for the use of substoichiometric amount of base. Ligand synthesis, catalyst/reaction optimization, substrate scope study results will be discussed in detail in the presentation.

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