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제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Photothermally triggered cytosolic drug delivery via endosome disruption using a funtionalized graphene oxide

등록일
2014년 9월 24일 15시 18분 21초
접수번호
1541
발표코드
POLY1-7 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 11시 : 30분
발표형식
분과기념
발표분야
고분자화학 - Current Trends in Self-healing Polymeric Materials
저자 및
공동저자
김원종
포항공과대학교(POSTECH) 화학과, Korea
In the present work, functionalized reduced graphene oxide (PEG-BPEI-rGO) has been developed as a nanotemplate for photothermally triggered cytosolic drug delivery by inducing endosomal disruption and subsequent drug release. PEG-BPEI-rGO has ability to load more amount of Doxorubicin (DOX) than unreduced PEG-BPEI-GO via π-π and hydrophobic interactions, showing high water stability. Loaded DOX could be efficiently released by glutathione (GSH) and photothermal effect of irradiated near IR (NIR) in test tubes as well as in cells. Finally, it was concluded that more cancer cell death efficacy was observed in PEG-BPEI-rGO/DOX complex-treated cells with NIR irradiation rather than that in no irradiation. Paclitaxel (PTX) is one of the most effective chemotherapeutic drugs used in breast, ovarian, lung, head and neck cancers. However PTX has very low solubility in water and physiological conditions. To enhance its solubility, PTX would be formed inclusion complex with β-cyclodextrin (β-CD). β-CD is a cup-shaped molecules that consists of 7 glucopyranoside units and has hydrophobic cavity and hydrophilic exterior. It has long-term biocompatibility, low toxicity and do not elicits any immune response. It has also well-known host-guest interactions with many small molecules and portions of large compounds, such as benzoate moiety of PTX. Herein, we designed self-assembled nanoparticles for PTX delivery toward tumor cell. Self-assembled nanoparticles were constructed through host-guest chemistry between PTX and CD. CD and PTX are covalently conjugated with poly maleic anhydrides that provide higher solubility of nanoparticles. This inclusion complex showed enhanced antitumor effect than PTX. In this study, we also developed novel nitric oxide (NO) delivery system using catecholamine and diazeniumdiolates. Although the surface NO delivery garners paramount importance in various biomedical applications, the prospect of local NO delivery strategies in implementing in widespread practical application is significantly impaired by the associated low NO-loading capacity, leaching out arising from the weak coating ability, heavy thickness (μm-mm). Herein, a novel surface nitric-oxide (NO) delivery system was developed. Simple two-step reactions comprising catecholamine and diazeniumdiolates enable virtually any material surfaces to release NO with appreciable storage. The modified surfaces showed the antibacterial activity without cytotoxicity. Hence our novel strategy presents the potential for various NO-mediated biomedical applications.

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