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Chemical Modification of Nucleic Acids towards Functional Nucleic Acid Systems

등록일
2006년 2월 16일 10시 32분 10초
접수번호
0947
발표코드
목18G6심 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 15시 : 30분
발표형식
심포지엄
발표분야
유기화학 - 유기1. Today and Tomorrow in Organic Chemistry - 1. Cornerstones in Organic Synthesis
저자 및
공동저자
김병현
포항공과대학교 화학과,
In recent years chemically modified oligonucleotides have become an area of increased research activity. These synthetic biopolymers have long been used as molecular probes to understand better the interaction between proteins and nucleic acids at molecular level. Also, over the past decade efforts are made to modify the native phosphodiester linkages to improve nuclease resistance and membrane permeation of naturally occurring oligonucleotides for therapeutic applications. Therefore, design and synthesis of modified oligonucleotides for a wide range of applications are of interest for bioorganic chemists and biologists. We would like to discuss some of our recent works on chemical modification of nucleosides and nucleotides of DNA. Our modified nucleic acid systems are classified into three major parts, namely, modified nucleosides, functional ODNs, and fluorescent ODNs.

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