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  • 02월 26일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제115회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Phenylboronic Acid-Sugar Grafted Polymer Architecture as Tumor Targetable and Dual-Stimuli Responsive Gene Carrier

등록일
2015년 2월 12일 17시 20분 11초
접수번호
1234
발표코드
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발표시간
금 11시 : 30분
발표형식
구두발표
발표분야
고분자화학 - General Oral Presentation
저자 및
공동저자
김진환, 김원종*
포항공과대학교(POSTECH) 화학과, Korea
We present herein a cationic polymer structure composed of phenylboronic acid (PBA) and sugar installed polyethylenimine (PEI) and polyethyleneglycol (PEG). The chemical bonding of PBAs with diols in sugar enabled the cross-linking of low molecular weight PEI to high molecular weight, resulting in better interaction with anionic DNA for gene delivery. Inside the cell, the binding of PBA and sugar was disrupted by both acidic endosomal pH and intracellular ATP, followed by effective release of gene contents. This dual stimuli-responsive gene release assisted the polymer to deliver DNA for high transfection efficiency with low cytotoxicity. In addition, PEGylation with PBA moiety facilitated the binding of polymer/DNA polyplexes to sialylated glycoprotein which is overexpressed on the tumor cell membrane, thus provided high tumor targeting ability. Therapeutic application of our polymer was demonstrated as anti-angiogenic gene delivery agent for tumor growth inhibition. Our judicious designed polymer structure based on PBA provides an enormous potential of gene delivery agent for effective gene therapy in a stimuli-responsive, tumor targetable manner.

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