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  • 02월 26일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제115회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Therapeutic effect of phytochemical-stabilized gold nanoparticles coated on hydrocolloid membrane in cutaneous wound healing

2015년 2월 25일 14시 31분 11초
ANAL.P-580 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 15일 (수요일) 16:00~19:00
저자 및
오상진, 이재범1,*
부산대학교 인지메카트로닉스공학과, Korea
1부산대학교 나노메디컬공학과, Korea

Acute healing of dermatological wound is of importance because of no longer infection as well as the decrease of post-treatment side effects such as hypo-pigmentation or permanent scarring and cosmetic reason. In this article, we report therapeutic effects of pAuNPs that are coated on hydrocolloid membrane (HCM) for curing cutaneous wound skin because both pAuNPs and HCM show excellent biocompatibility and phytochemicals can be an antioxidative agent. The remedial effects of pAuNPs on skin regeneration and angiogenesis were examined in injured skins of Sprague Dawley (SD) rats after the pAuNP-coated hydrocolloid membrane (pAuNP-HCM) was applied for 15 days. The rate of wound closure was about 30 % faster in pAuNP-HCM treated group than that of gauze (GZ) or HCM treated group in first 5 days. Furthermore, wound widths in pAuNP-HCM treated group were significantly decreased in the treatment day 5 ~ 15 after the injury when compared with other groups. Also, significant increase of collagen expression, as well as a decrease of matrix metalloproteinase (MMP) -1 expression and TNG-1beta concentration were observed in the pAuNP-HCM treated group at the day 5. Wound tissue applied with pAuNP-HCM showed enhancement of vascular endothelial growth factor (VEGF), Ang-1 and Ang-2 expression at the day 10. Then, these values were maintained as consistent level until the day 15. Furthermore, notice that the activity of superoxide dismutase (SOD) was significantly increased in skin tissue of the pAuNP-HCM treated group, compared with the GZ or HCM treated group. In conclusion, the pAuNP-HCM may accelerate the process of wound healing in injured skin of SD rats through the synergetic regulation of angiogenesis and connective tissue formation as well as stimulation of anti-oxidant effects.