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학술발표회초록보기

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  • 02월 26일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제115회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Surface-engineered Nanomaterials as X-ray Absorbing Adjuvant Agents for Auger-mediated Chemo-radiation

등록일
2015년 2월 25일 21시 03분 10초
접수번호
1361
발표코드
MAT1-1 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 09시 : 30분
발표형식
심포지엄
발표분야
재료화학 - Recent Trends in Soft Nano/Micro Materials
저자 및
공동저자
이상민
가톨릭대학교 화학과, Korea
We demonstrate a prototype approach to formulating gold nanoparticle (AuNP)-based X-ray absorbing adjuvant agents through surface-engineering of cisplatin pharmacophore (Pt) with lipoic acid-modified polyacrylate (Pt-AuNPs). Design of Pt-AuNPs was examined and further validated using a combination of physicochemical characterization methods. Our results show Pt-AuNPs exhibits very high capacity for Pt-loading via the mechanism of multidentate coordination between Pt(II) ions and surface-bound polyacrylate. The Pt-AuNP vector demonstrated excellent colloidal stability in an acid-sensitive manner that enables Pt drug-release, and exhibited high in vitro cytotoxicity to the cancer cell lines MCF-7 and SK-OV-3. Secondary electron emissions from both Pt(II) and AuNPs are triggered by an external ionizing radiation source via the Auger cascade. As a result, Pt-AuNPs exhibit therapeutic potential as an adjuvant agent for concurrent chemo-radiation cancer therapy

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