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학술발표회초록보기

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  • 02월 26일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제115회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Peptide functionalized gold nanoparticles for novel targeting agent towards Brain Glioma stem cell marker CD133

등록일
2015년 2월 26일 09시 37분 04초
접수번호
1372
발표코드
BIO.P-646 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 15일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
조준행, 윤문영1,*
한양대학교 자연과학대학, Korea
1한양대학교 화학과, Korea
In the cancer stem cells (CSCs) model, only a small proportion of tumor cells are able to self-renew extensively, while the bulk of cells proceed to differentiate into committed heterogeneous clones. On the basis of the involvement of CSCs in tumourigenesis and treatment resistance, it is conceivable that only eradication of CSCs can lead to a cancer cure. CD133, also known as prominin-1 (PROM-1), is a 5-transmembrane glycoprotein with several isoforms of unknown physiological or pathological function. CD133+ cells was firstly identified as a cancer initiating cell in brain tumor and contributor to the CSC population. Therefore, CD133 are an important target candidate for prevention of relapse and disease progression in brain tumor. In the previous study, we screened the peptide which have higher binding potency to target protein in vitro. To further characterization of found peptides, we investigate the binding properties on cellular level. In addition with this, the peptide conjugated to Gold nanoparticle for novel diagnostic approach.

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