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초록문의 abstract@kcsnet.or.kr

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  • 02월 26일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제115회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Identification of natural product inhibitors for slingshot homologs

등록일
2015년 2월 26일 14시 19분 36초
접수번호
1437
발표코드
BIO.P-648 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 15일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
이영근, 이선영, 강효진, 정상전*
동국대학교 화학과, Korea
The level of protein tyrosine phosphorylation is maintained by coordinated catalysis of protein tyrosine phosphatases (PTPs) and protein tyrosine kinases (PTKs). Protein phosphatase slingshot homologs (SSH), members of dual specific phosphatases (DUSPs), consist of SSH-1, -2 and -3. Each member plays an essential role in controlling actin dynamics by regulating cofilin/ADF activity. Cofilin is important in actin dynamics relevant to states of various diseases such as neurodegenerative diseases, vascular diseases, phagocytic ingestion event for infective microorganism, as well as cancers. We have screened natural product library for inhibitors of SSHs, which may offer a clue to develop therapeutics for aforementioned actin dynamics-related diseases. As a result, we identified seven natural products with SSHs inhibitory activity Interestingly, one of the inhibitors showed selective inhibition to SSH?2 over SSH-1 and -3. Further, we determined type of inhibition by each inhibitor and Ki values. Additionally, binding site prediction of the inhibitors were performed with a crystal structure of SSH-2.

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