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학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

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  • 02월 26일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제115회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Natural Product Inhibitors for Cdc25 Phosphatases

등록일
2015년 2월 26일 14시 54분 45초
접수번호
1446
발표코드
BIO.P-649 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 15일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
박기선, 강효진, 정상전*
동국대학교 화학과, Korea
Cell division cycle 25 phosphatases (Cdc25s) are dual-specificity protein phosphatases that play a key role in the cell cycle transition by dephosphorylating CDK/cyclin complexes. Overexpression of Cdc25s has been observed in a variety of cancers with tumor aggressiveness and poor prognosis. Therefore, Cdc25s have been regarded as attractive drug targets for anticancer therapy, meaning that discovery of selective Cdc25s’ inhibitors may be a potential cancer therapeutic approach. We have screened 658 natural compounds for Cdc25 inhibitors through HTS. For several hit compounds showing slow binding and noncompetitive inhibition, we determined IC50 and Ki values, confirming mode of inhibition, and defined a potential binding site through molecular docking study. Furthermore, we treated the breast cancer cells with the selected Cdc25s’ inhibitors to test if they show anticancer effect in vitro.

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