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  • 02월 26일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제115회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Identification of a Potent Inhibitor of Human Vaccinia-H1 Related (VHR) Phosphatase and its Anti-proliferative Activity against Cervix Cancer Cells

등록일
2015년 2월 26일 15시 04분 49초
접수번호
1451
발표코드
BIO.P-652 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 15일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
노경민, 강효진*, 정상전*
동국대학교 화학과, Korea
Human vaccinia-H1 related (VHR) phosphatase, encoded by dual specificity phosphatase 3 (DUSP3) gene, is one of the smallest known phosphatase with only 185 amino acids and regulates phosphorylation states of protein. Maintaining the proper protein tyrosine phosphorylation state has been implicated in various human diseases including cancer, type 2 diabetes and obesity. Especially, VHR has been reported that loss of VHR activity cause cell cycle arrest in HeLa cells, suggesting that identification of its selective inhibitors expected potential anticancer drugs. Natural products have been regarded as good source for development of new drugs. Here, we screened natural product library for VHR inhibition to identify hit compounds. Furthermore, kinetic evaluation of the hit compounds identified a potent inhibitor with nM Ki and the hit compounds decreased the proliferation of cervix cancer cells. These compounds may be a promising targeted therapeutic drugs for cervix cancer.

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