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02월 26일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능
제115회 대한화학회 학술발표회, 총회 및 기기전시회 안내
The chemical structures of newely identified analogures of drugs in adulterated foods
2015년 2월 26일 15시 08분 26초
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목 11시 : 35분
Recent Trends in Separation Analysis I: Fundamentals
식품의약품안전평가원 첨단분석팀, Korea
The various forms of dietary supplements have been developed, because consumer demand for dietary supplements that support their new or continuing healthy lifestyle has increased steadily in recent years. The various forms of analogues of erectile dysfunction and anti-obesity drugs in the dietary supplements which produced to avoid skillfully the regulation of the Ministry of Food and Drug Safety have been increased. Recently, the most widely prescribed drug, sibutramine, was withdrawn from the market. However, phosphodiesterase-5 (PDE-5) inhibitors have been developed to treat erectile dysfunction (ED) and various ED drugs such as sildenafil, tadalafil, vardenafil, and mirodenafil have come onto the market. Some manufacturers dope synthetic drugs into these products to increase treatment efficacy. To date, the 57 analogues of drugs such as PDE-5 inhibitors and sibutramine in adulterated health food products have been identified and our laboratory has been continuously identifying these kind of drugs. The 8 illegal analogues of drugs identified in adulterated foods in 2013 to 2014 were registered in the Criteria and Standards for Food by MFDS and the analogues are continuously being discovered. The 6 out of 8 newely identified analogues of drugs have been first reported in Korea. The structures of 8 analogues of erectile dysfunction(ED) were consistent with a proproxyphenyl-linked sildenafil, an acetylated product of aminotadalafil or methylated tadalafil, and the new analogues were also found as impurities in illegal analogues of drugs. Many analogues of ED may exist because of their chemical structures and the analogues are becoming increasingly diversified and sophisticated in terms of their products and processes. Therefore, it is essential to continuously monitor existing and newly identified analogues of ED, along with elucidating its structural characteristics.
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