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  • 02월 26일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제115회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Magnetotactic Self-Assembled Peptide Architectures

2015년 2월 26일 16시 00분 49초
POLY.P-69 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 15일 (수요일) 16:00~19:00
저자 및
권선범, 이희승*
한국과학기술원(KAIST) 화학과, Korea
Biological molecular machines capable of converting chemical energy into mechanical work regulate a wide variety of biological processes in living organisms. Motor proteins, one of the most well-known biological machinery, perform their essential motile functions such as cargo transport, muscle contraction. Over the past few decades, inspired by the protein machines, considerable advance has been made in controlling the motions of synthetic molecules by virtue of the pioneering efforts of organic chemists. In most precedent studies, movable parts of the synthetic machines were shepherded by using nonbiological molecular scaffolds with unique structural constraints such as mechanical interlocking, overcrowded alkenes. However, de novo design of a well-defined, artificial molecular machine from biological elements still poses a great challenge due to the inherent complexities such as unpredictable folding and agglomeration. Protein-based molecular machines, in particular, are highly complicated supramolecular ensembles obtained from the sophisticated integration and precise positional displacement of subunit structures. And therefore it is inevitably difficult to rectify the subtle motions at the molecular level from protein-based molecular assemblies. Here we show a very simple, ingenious demonstration that the assemblies of peptide foldamers, artificial mimicry of protein fragments, are able to be directly utilized as molecular machines biased by external magnetic field.